Substituted...

Details Substituted... Substituted...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2317834

A chiral compound is described, in racemic, (R)- or (S)- form, which is a 2-(2,6-dioxo-3-fluoropiperidin-3-yl)- isoindoline of the formula: (see formula I) in which Y is oxygen or H2 and each of R1, R2, R3, and R4, independently of the others, is hydrogen, halo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or amino, or the acid addition salts of said 2-(2,6-dioxo-3- fluoropiperidin-3-yl)-isoindolines which contain a nitrogen atom capable of being protonated. 1-Oxo-2-(2,6-dioxo-3- fluoropiperidin-3-yl)-isoindolines and 1,3-dioxo-2-(2,6- dioxo-3-fluoropiperidin-3-yl)-isoindolines reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3--fluoropiperidin-3-yl)- isoindoline.

L'invention concerne des 1-oxo-2-(2,6-dioxo-3-fluoropipéridine-3-yl)isoindolines et des 1,3-dioxo-2-(2,6-dioxo-3-fluoropipéridine-3-yl)isoindolines pour réduire les taux de cytokines inflammatoires tels que les taux de TNF - alpha chez le mammifère. Un mode de réalisation classique est le 1,3-dioxo-2-(2,6-dioxo-3-fluoropipéridine-3-yl)-isoindoline.

Affiliated with

Also associated with

Rating

Substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1375339