Pyrrolidine derivatives as prostaglandin modulators

Details Pyrrolidine derivatives as prostaglandin modulators Pyrrolidine derivatives as prostaglandin modulators

C - Chemistry, Metallurgy

07

D

C07D 207/10 (2006.01) A61K 31/40 (2006.01) C07D 207/36 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2469075

Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

L'invention concerne des composés de pyrrolidine substituée, ainsi que des traitements et une composition pharmaceutique qui utilise ou contient un ou plusieurs des composés décrits. Ces composés sont utiles pour divers traitements, notamment le traitement ou la prévention du déclenchement prématuré du travail, des dysménorrhées, de l'asthme, de l'hypertension, des troubles d'infertilité ou de fécondité, de la coagulation sanguine indésirable, de la prééclampsie et de l'éclampsie, des troubles éosinophiliques, des dysfonctions sexuelles, de l'ostéoporose et d'autres pathologies osseuses destructives, et d'autres pathologies et troubles associés à des composés de la famille des prostaglandines. Dans un des aspects préférés, l'invention concerne l'administration conjointe à un sujet d'un composé de pyrrolidine substituée et d'un composé inhibiteur de la phosphodiestérase.

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