Cryptococcal mannoproteins or equivalents thereof for use in...

Details Cryptococcal mannoproteins or equivalents thereof for use in... Cryptococcal mannoproteins or equivalents thereof for use in...

C - Chemistry, Metallurgy

07

K

C07K 14/37 (2006.01) A61K 38/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2402311

The present invention is among others concerned with suppressing neutrophil migraation and the prevention of damage from neutrophil migration. Provided is a proteinaceous substance derivable from Cryptococcus neoformans and capable of interfering with neutrophil migration in a mammalian host. Also provided are functional equivalents of such a proteinaceous substance and the use of this substance and/or equivalent in the preparation of a medicament.

L'invention vise entre autres à freiner la migration neutrophile et à prévenir le dommage causé par cette migration. Elle concerne une substance protéique pouvant être dérivée de Cryptococcus neoformans et capable de faire obstacle à une migration neutrophile chez un hôte mammifère. Elle concerne aussi des équivalents fonctionnels de cette substance protéique et l'utilisation de cette substance et/ou de son équivalent dans la préparation d'un médicament.

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