Humanized anti-ngf antibodies

Details Humanized anti-ngf antibodies Humanized anti-ngf antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01)

Patent

CA 2688944

A humanized anti-NGF antibody or a fragment thereof which maintains binding activity to NGF, wherein the humanized anti-NGF antibody comprises, (a) a VH region having a first CDR comprising the amino acid sequence GFSLTNNNVNW, a second CDR comprising the amino acid sequence GVWAGGATDYNSALKS, and a third CDR comprising the amino acid sequence DGGYSSSTLYAMDA; and (b) a VL region having a first CDR comrising the amino acid sequence RASEDIYNALA, a second CDR comprising the amino acid sequence HT, and a third CDR sequence comprising the amino acid sequence QHYFHYPRT.

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