A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/42 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01)
Patent
CA 2457196
The present invention relates to compositions containing itraconazole with a greatly increased bioavailability and their preparation methods. More specifically, the present invention relates to compositions containing itraconazole which is a sparingly-soluble drug, fatty acid or fatty alcohol and surfactant and their preparation methods. Compositions according to the present invention act as Self-MicroEmulsifying Drug Delivery System(SMEDDS) wherein itraconazole which is a sparingly-soluble drug is dissolved and dispersed to form a mocoidal phase, and the mocoidal phase is dissolved in water to form microemulsion. And because of increased dissolution property and increased bioavailability, compositions according to the present invention show equal efficacy using less amount than commercial pharmaceutical preparations such as sporanox capsule and are cheaper rather than the commercial pharmaceutical preparations such as sporanox capsule.
L'invention concerne des compositions contenant de l'itraconazole à biodisponibilité hautement améliorée ainsi que leurs procédés de préparation. Plus particulièrement, l'invention concerne des compositions contenant de l'itraconazole, qui est un médicament faiblement soluble, un acide gras ou un alcool gras, et un tensioactif ; l'invention concernant également les procédés de préparation de ces compostions. Par ailleurs, ces compositions agissent comme un système d'administration de médicament auto-microémulsifiant (SMEDDS) dans lequel l'itraconazole est dissous et dispersé pour former une phase mucoïdale laquelle est dissoute dans l'eau pour former la microémulsion. En raison de leurs propriétés améliorées en terme de dissolution et de biodisponibilité, ces compositions présentent, à petite dose, une efficacité égale à celle des préparations pharmaceutiques commercialisées, telles que les comprimés de Sporanox, tout en étant moins chères.
Choi Choon Young
Lee Beom Jin
Lee Dong Won
Lee Beom Jin
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Won Jin Biopharma Co. Ltd.
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