A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 47/48 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 9/14 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2622904
The present invention is directed to the formation of structures in situ through the principles of ligand binding. These structures are efficacious, for example, for tissue repair as well as for short- and long-term disease and condition management. According to one aspect of the invention, an injectable composition comprising self-assembling nanoparticles is provided. The self- assembling nanoparticles include: (a) a nanoparticle portion, (b) tissue binding ligands attached to the nanoparticle portion, which cause preferential binding and accumulation of the nanoparticles at one or more targeted tissue locations upon injection of the composition into the body, and (c) first and second interparticle binding ligands attached to the nanoparticle portion, which cause interparticle binding upon injection of the composition into the body.
L'invention concerne la formation de structures in situ selon les principes de liaison de ligand. Les structures de l'invention sont efficaces, par exemple, pour la réparation de tissus et la gestion de maladies et d'états à court et à long terme. Selon un aspect de l'invention, une composition injectable comprenant des nanoparticules d'auto-assemblage est utilisée. Les nanoparticules d'auto-assemblage comprennent : (a) une partie nanoparticulaire ; (b) des ligands de liaison à des tissus fixés sur la partie nanoparticulaire, qui assurent une liaison préférentielle et une accumulation des nanoparticules au niveau d'un ou de plusieurs sites de tissus ciblés après injection de la composition dans le corps ; et (c) un premier et un deuxième ligand de liaison interparticulaire fixés sur la partie nanoparticulaire, qui assurent une liaison interparticulaire après injection de la composition dans le corps.
Boston Scientific Limited
Kirby Eades Gale Baker
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