Stabilized therapeutic small helical antiviral peptides

Details Stabilized therapeutic small helical antiviral peptides Stabilized therapeutic small helical antiviral peptides

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61K 51/08 (2006.01) A61P 31/12 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2665186

Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions.

Cette invention concerne des peptides contraints qui inhibent l'assemblage du VIH. Cette invention concerne également des compositions pharmaceutiques comprenant ces peptides, ainsi que des procédés d'inhibition de la réplication d'un virus contenant une capside dans une cellule. Cette invention concerne en outre des méthodes de traitement d'un mammifère infecté par un virus contenant une capside, de même que des méthodes de traitement d'un mammifère présentant un risque d'infection par un virus contenant une capside. Cette invention concerne enfin des procédés de production de ces peptides, ainsi que des utilisations des peptides et compositions pharmaceutiques susmentionnés.

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