Subtle mitochondrial mutations as tumor markers

Details Subtle mitochondrial mutations as tumor markers Subtle mitochondrial mutations as tumor markers

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2340175

The accumulation of homoplasmic somatic mutations has been observed in the mitochondrial DNA of certain tumor cells. The presence or a recurrence of a tumor can be detected by determining the presence of single basepair mutations in the mitochondrial genome from a cell sample of a patient.

On a observé une accumulation de mutations somatiques homoplasmiques dans l'ADN mitochondrial de certaines cellules tumorales. On peut détecter la présence ou la récurrence d'une tumeur par détermination de la présence de mutations dans une seule paire de bases, dans le génome mitochondrial, à partir d'un échantillon cellulaire d'un patient.

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