Indole derivatives and medicinal compositions containing the...

Details Indole derivatives and medicinal compositions containing the... Indole derivatives and medicinal compositions containing the...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2321547

The present invention relates to indole derivatives represented by the general formula: (see formula I) (wherein R represents an ethyl group or a 2,2,2-trifluoroethyl group; Y represents a hydroxy group or a pivaloyloxy group; and the carbon atom marked with (R) represents a carbon atom in (R) configuration) and pharmaceutically acceptable salts thereof, which have potent and prolonged reducing effects on intraocular pressure and are useful as agents for lowering intraocular pressure.

L'invention concerne des dérivés de l'indole représentés par la formule générale (I), dans laquelle R désigne un éthyle ou un trifluoro-2,2,2-éthyle; Y désigne un hydroxy ou un pivaloyloxy, l'atome de carbone marqué (R) indiquant celui qui présente la configuration R. Ces dérivés, ainsi que leurs sels pharmaceutiquement acceptables, présentent un effet remarquable et de longue durée d'abaissement de la tension oculaire et sont utilisés en conséquence comme médicaments pour l'abaissement de la tension oculaire.

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