C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/22 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) C07C 311/21 (2006.01) C07C 311/47 (2006.01) C07C 311/60 (2006.01) C07D 207/30 (2006.01)
Patent
CA 2196388
Diaryldicarboxylic acid diguanidides of the formula I (see fig. I) I in which R(1) to R(10) have the meanings indicated in the claims, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris.They also inhibit, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.
Les diguanidides d'acide diaryldicarboxylique de formule I (voir fig. I), dans lesquels R(1) à R(10) ont la signification donnée dans les revendications, conviennent comme antiarythmisants, avec une composante cardioprotectrice pour la prévention et le traitement de l'infarctus ainsi que pour le traitement de l'angine de poitrine. Ils empêchent également, de façon préventive, les processus pathophysiologiques lors de l'apparition de lésions d'origine ischémique, et suppriment notamment les arythmies cardiaques d'origine ischémique.
Albus Udo
Brendel Joachim
Kleemann Heinz-Werner
Lang Hans Jochen
Scholz Wolfgang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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