Surface modified liposomes

Details Surface modified liposomes Surface modified liposomes

G - Physics

01

N

G01N 33/544 (2006.01) A61K 9/127 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2073735

P-1854 SURFACE MODIFIED LIPOSOMES ABSTRACT OF THE DISCLOSURE A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants are enzymes or dyes. In the most preferred reagents, the antibody and sulfonate- containing group are covalently bonded to the liposome surface through a connecting group which includes a succinimidyl group resulting from addition of the ligand or sulfonate-containing group to a maleimidyl group. The invention includes a kit of materials for performing an assay using the reagent of the invention as the tracer.

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