Recombinant n-smases and nucleic acids encoding same

Details Recombinant n-smases and nucleic acids encoding same Recombinant n-smases and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07H 21/04 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/16 (2006.01) C12N 9/20 (2006.01) C12N 9/22 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2276090

Isolated nucleic acids are provided that encode human neutral sphingomyelinase (N-SMase) and N-SMase fragments and derivatives capable of hybridizing to such N-SMase-encoding nucleic acids. The invention also includes isolated recombinant human neutral sphingomyelinase (N-SMase) and N-SMase fragments and derivatives are also provided. Novel assays are also provided to identify compounds useful in the diagnosis or treatment of human neutral sphingomyelinase related disorders.

Les acides nucléiques isolés décrits codent la sphingomyélinase humaine neutre (N-SMase) ainsi que des fragments de N-SMase et leurs dérivés pouvant être hybridés en de tels acides nucléiques codant la N-SMase. L'invention porte aussi sur la sphingomyélinase humaine neutre recombinée (N-SMase), ainsi que sur les fragments de N-SMase et leurs dérivés. Les nouveaux dosages décrits permettent d'identifier des composés utiles dans le diagnostic et le traitement des troubles relatifs à la sphingomyélinase humaine neutre.

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