Benzylimidazolyl substituted 2-quinoline and quinazoline...

Details Benzylimidazolyl substituted 2-quinoline and quinazoline... Benzylimidazolyl substituted 2-quinoline and quinazoline...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2478813

This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6 and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine to treat e.g. cancer.

L'invention concerne des nouveaux composés de formule générale (I), dans laquelle r, t, Y?1¿, Y?2¿, R?1¿, R?2¿, R?3¿, R?5¿, R?6¿ et R?7¿ ont la signification indiquée dans la description, qui présentent une activité inhibitrice de farnésyl transférase. L'invention concerne également leur préparation, des compositions les contenant ainsi que leur utilisation en tant que médicaments destinés à traiter par exemple le cancer.

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