A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/02 (2006.01) A61K 35/12 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01)
Patent
CA 2395637
The invention is directed to methods for producing a decellularized organ or part of an organ. A decellularized organ is produced using an isolated organ mechanically agitated to remove cellular membranes surrounding the isolated organ without destroying the interstitial structure of the organ. After the cellular membrane is removed, the isolated organ is exposed to a solubilizing fluid that extracts cellular material without dissolving the interstitial structure of the organ. A washing fluid is used to remove the solubilized components,leaving behind a decellularized organ.
L'invention concerne des méthodes de production d'un organe ou d'une partie d'organe débarrassé(e) de la membrane cellulaire. Ladite méthode consiste à agiter mécaniquement un organe isolé, de manière que les membranes cellulaires l'entourant soient enlevées sans que cela détruise sa structure interstitielle. Une fois la membrane cellulaire enlevée, l'organe isolé est exposé à un fluide de solubilisation qui extrait la matière cellulaire sans dissoudre la structure interstitielle de l'organe. Un fluide de lavage est utilisé pour l'enlèvement des composants solubilisés, un organe débarrassé de sa membrane cellulaire étant ainsi obtenu.
Children's Medical Center Corporation
Riches Mckenzie & Herbert Llp
LandOfFree
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