Composition for nasal administration

Details Composition for nasal administration Composition for nasal administration

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/485 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2127805

A composition for nasal administration of polar metabolites of opioid analgesics comprises a polar metabolite of an opioid analgesic and an absorption promoting agent. Preferred metabolites morphine-6-glucuronide and morphine-6-sulphate. A preferred absorption promoting agent is chitosan but other suitable agents include cationic polymers, bioadhesive agents, surface active agents, fatty acids, chelating agents, mucolytic agents, cyclodextrin, microsphere preparations or combinations thereof.

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