Gene methylation in cancer diagnosis

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G06F 19/00 (2011.01) C07H 21/00 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2652975

The present invention provides DNA marker sequences that are differentially methylated in samples from normal individuals and individuals with breast cancer, including ductal carcinoma. The invention further provides methods of identifying differentially methylated DNA marker sequences and their use the detection and diagnosis of breast cancer.

La présente invention concerne des séquences marqueurs d'ADN qui ont subi une méthylation différentielle dans des échantillons provenant d'individus normaux et d'individus atteints d'un cancer du sein, y compris d'un carcinome intracanalaire. L'invention concerne en outre des procédés d'identification de séquences marqueurs d'ADN ayant subi une méthylation différentielle et leur utilisation, ainsi que la détection et le diagnostic d'un cancer du sein.

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