A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/10 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2688544
The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O2 measurements by electron paramagnetic resonance spectroscopy.
La présente invention concerne des esters d'alcanoyloxyméthyle de nitroxydes qui sont lipophiles et séparables, qui traversent la barrière hématoencéphalique et dont, après hydrolyse avec des estérases intracellulaires, les nitroxydes anioniques correspondants sont emprisonnés à l'intérieur de la cellule à des niveaux suffisants pour permettre des mesures de O2 par spectroscopie par résonance paramagnétique électronique.
Kao Joseph P.y.
Liu Ke-Jian
Rosen Gerald M.
Kirby Eades Gale Baker
University Of Maryland - Biotechnology Institute
University Of Maryland At Baltimore
University Of New Mexico
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