Antisense nucleic acid molecules targeted to type i...

Details Antisense nucleic acid molecules targeted to type i... Antisense nucleic acid molecules targeted to type i...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C12N 9/64 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2402816

The present invention relates to an antisense to inhibit melanoma invasion, to an expression vector and to a method for substantially inhibiting tumor cell invasion of an extracellular matrix (ECM) and other invasive processes such as angiogenesis, and particularly plasmin-mediated proteolysis thereof in a patient, by suppression of type I collagenase (MMP-1) expression in the patient.

L'invention concerne un antisens, destiné à inhiber l'invasion de mélanome, un vecteur d'expression, ainsi qu'un procédé destiné à inhiber sensiblement une invasion, par des cellules tumorales, d'une matrice extracellulaire, et à inhiber d'autres processus invasifs, tels que l'angiogenèse, et notamment la protéolyse de celle-ci, induite par plasmine, par suppression de l'expression de la collagénase de type I chez un patient.

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