Adenovirus carrying gag gene hiv vaccine

Details Adenovirus carrying gag gene hiv vaccine Adenovirus carrying gag gene hiv vaccine

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/21 (2006.01) C07H 21/04 (2006.01) C07K 14/16 (2006.01) C12N 15/00 (2006.01) C12N 15/861 (2006.01) C12P 21/04 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2378539

An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.

L'invention concerne un vecteur adénoviral véhiculant un gène gag à codons optimisés, ainsi qu'un promoteur hétérologue et un terminateur de transcription. Ce vaccin viral permet d'empêcher efficacement l'infection à VIH lorsqu'il est administré à des êtres humains soit seul, soit dans le cadre d'un régime de primo immunisation/rappel avec un plasmide vaccin.

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