A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 49/16 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2565827
Methods for improving the biological and pharmaceutical properties of bispecific binding agents are described herein where the bispecific binding agent are able to target cells by a high affinity binding domain to a first cell surface marker that does not induce a significant biological effect and a low affinity binding domain that binds specifically to a second cell surface marker, causing a significant and desired biological effect. Compositions of such bispecific binding agents, uses for them, and kits containing them are also provided.
L'invention concerne des procédés permettant d'améliorer les propriétés biologiques et pharmaceutiques d'agents de liaison bispécifiques. Selon lesdits procédés, lesdits agents de liaison bispécifiques peuvent cibler des cellules au moyen d'un domaine de liaison d'affinité élevée se liant à un premier marqueur de surface cellulaire qui n'induit pas d'effet biologique notable, et d'un domaine de liaison de faible affinité qui se lie de manière spécifique à un deuxième marqueur de surface cellulaire, ce qui permet d'obtenir un effet biologique désiré et notable. L'invention concerne également des compositions à base desdits agents de liaison bispécifiques, leurs utilisations, ainsi que des kits les contenant.
Nielsen Ulrik B.
Schoeberl Birgit M.
Borden Ladner Gervais Llp
Merrimack Pharmaceuticals Inc.
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