Modified chimeric polypeptides with improved pharmacokinetic...

Details Modified chimeric polypeptides with improved pharmacokinetic... Modified chimeric polypeptides with improved pharmacokinetic...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01) C07K 14/71 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/18 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2376379

Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.

La présente invention concerne des polypeptides chimériques modifiés à pharmacocinétique améliorée. L'invention concerne plus particulièrement des polypeptides récepteurs Flt1 chimériques modifiés de façon à en améliorer le profil pharmacocinétique. L'invention concerne également des procédés de fabrication et d'utilisation de ces polypeptides modifiés, et notamment pour diminuer ou bloquer les fuites de plasma et/ou la perméabilité vasculaire chez un mammifère.

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