C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/077 (2010.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2379683
The present invention provides a molecular marker for the identification of pluripotent pre-mesenchymal, pre-hematopoietic stem cells. The invention further provides primitive progenitor cells identified by the molecular marker. Such cells have the potential to differentiate into both mesenchymal and hematopoietic phenotypes, as determined by a proliferative response to inductive growth factors and cytokines, and by their morphologic and cytochemical features.
La présente invention concerne un marqueur moléculaire destiné à l'identification de cellules souches multipotentes pré-mésenchymateuses pré-hématopoïétiques. L'invention concerne aussi des cellules progénitrices primitives identifiées au moyen de ce marqueur moléculaire. Ces cellules ont la capacité de différentiation entre les phénotypes mésenchymateux et hématopoïétiques, définis par une réponse proliférative aux cytokines facteurs de croissance inductifs ainsi que par leurs caractéristiques morphologiques et cytochimiques.
Gordon Erlinda M.
Hall Frederick L.
Smart & Biggar
University Of Southern California
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