A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01)
Patent
CA 2603084
The present invention is directed to a composition comprising a nanoparticulate cyclosporine having improved bioavailability. The nanoparticulate cyclosporine particles of the composition have an effective average particle size of less than about 2000 nm in diameter and are useful in the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases. The invention also relates to a controlled release composition comprising a cyclosporine or a nanoparticulate cyclosporine that in operation delivers the drug in a pulsed or bimodal manner for the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases.
La présente invention concerne une composition contenant une cyclosporine nanoparticulaire à biodisponibilité améliorée. Les particules de cyclosporine nanoparticulaire de la composition présentent une taille moyenne effective de particules inférieure à environ 2 000 nm en diamètre et sont utiles dans la prévention et le traitement du rejet de greffe d'organe, de maladies auto-immunes telles que le psoriasis, l'arthrite rhumatoïde et d'autres maladies associées. Cette invention concerne également une composition à libération contrôlée contenant une cyclosporine ou une cyclosporine nanoparticulaire et qui, en action, permet la libération pulsatile ou bimodale du médicament pour la prévention et le traitement du rejet de greffe d'organe, de maladies auto-immunes telles que le psoriasis, l'arthrite rhumatoïde et d'autres maladies associées.
Jenkins Scott
Liversidge Gary
Elan Pharma International Limited
Kirby Eades Gale Baker
LandOfFree
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