Thiolactones

Details Thiolactones Thiolactones

C - Chemistry, Metallurgy

07

D

C07D 335/02 (2006.01) C07D 335/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2518234

This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-.szlig. activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

L'invention concerne des nouveaux composés, des compositions pharmaceutiques et des trousses de diagnostic comprenant ces composés, ainsi que des méthodes d'utilisation desdits composés pour inhiber l'activité enzymatique de la NAALADase, pour détecter des maladies caractérisées par une modification des taux de NAALADase, pour inhiber l'angiogenèse, pour produire une activité TGF-.beta. ou une activité neuronale, et pour traiter une anomalie liée au glutamate, un trouble compulsif, la neuropathie, la douleur, une maladie prostatique, le cancer, la maladie de Huntington, le diabète, un trouble rétinien ou le glaucome.

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