A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2747195
A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent under physiological conditions through a reaction driven by chemical instability. Accordingly, the dipeptide element provides a means of linking various compounds to known medicinal agents wherein the compounds are subsequently released from the medicinal agent after a predetermined time of exposure to physiological conditions. For example, the dipeptide can be linked to an active site of a drug to form a prodrug and/or the dipeptide may comprise a depot polymer to sequester an injectable composition comprising the complex at the point of admin-istration.
La présente invention concerne un élément dipeptidique auto-clivant non-enzymatique qui peut se lier à des agents médicinaux connus par une liaison amide. Le dipeptide sera spontanément clivé de l'agent médicinal dans les conditions physiologiques, à travers une réaction dirigée par l'instabilité chimique. Ainsi, l'élément dipeptidique fournit un moyen de lier divers composés à des agents médicinaux connus, les composés étant ensuite libérés de l'agent médicinal après une durée prédéterminée d'exposition aux conditions physiologiques. Par exemple, le dipeptide peut être lié au site actif d'un médicament pour former un promédicament et/ou le dipeptide peut comprendre un polymère-dépôt destiné à séquestrer une composition injectable comprenant le complexe au point d'administration.
Indiana University Research And Technology Corporation
Smart & Biggar
LandOfFree
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