Method for producing olmesartan medoxomil

Details Method for producing olmesartan medoxomil Method for producing olmesartan medoxomil

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/4178 (2006.01) A61P 9/12 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2759163

Disclosed are: highly pure olmesartan medoxomil which contains a reduced amount of impurities such as olmesartan and olmesartan medoxomil dihydrate; and a method for producing the same. A method for producing highly pure olmesartan medoxomil characterized in that a water-containing solvent is used in the steps of trimethylating olmesartan and esterifying DMDO.

La présente invention concerne : de l'olmésartan médoxomil de pureté élevée contenant une quantité réduite d'impuretés telles que l'olmésartan et le dihydrate de l'olmésartan médoxomil ; et un procédé de production de celui-ci. Un procédé de production de l'olmésartan médoxomil de pureté élevée est caractérisé en ce qu'un solvant contenant de l'eau est utilisé lors des étapes consistant à triméthyler l'olmésartan et à estérifier le DMDO.

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