C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07H 7/06 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2604334
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
L'invention concerne des anticorps monoclonaux qui reconnaissent le complexe récepteur Récepteur 4/MD-2 de type Toll, et des anticorps monoclonaux qui reconnaissent le complexe TLR4/MD2 ainsi que TLR4 lorsque ce dernier ne forme pas de complexe avec MD-2. L'invention se rapporte en outre à des procédés d'utilisation des anticorps monoclonaux humanisés en thérapeutique. L'invention porte également sur des protéines chimères solubles, sur des procédés d'expression et de purification de protéines chimères solubles et sur des procédés d'utilisation de protéines chimères solubles en thérapeutique, dans des essais de criblage et dans la production d'anticorps.
Elson Greg
Leger Olivier
Novimmune S.a.
Ridout & Maybee Llp
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