Tetrazolyl-methylene amino acid derivatives

Details Tetrazolyl-methylene amino acid derivatives Tetrazolyl-methylene amino acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/41 (2006.01) A61K 31/4427 (2006.01) C07D 257/04 (2006.01)

Patent

CA 2589718

This invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R1 , Q, W1 , W2 , R2a, L1, and R3, the pharmaceutical composition, the method of treating, and the therapeutic combination are as defined in the specification.

La présente invention concerne un composé représenté par la formule (I) ou un sel pharmaceutiquement acceptable de ce dernier; une composition pharmaceutique; une méthode de traitement d'une maladie médiée par une enzyme MMP-13 chez un mammifère; et une combinaison thérapeutique contenant au moins deux constituants pharmaceutiquement actifs. R1 , Q, W1 , W2 , R2a, L1 et R3, la composition pharmaceutique, la méthode de traitement et la combinaison thérapeutique sont tels que dans le descriptif. Formule (I)

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