Recombinant proteins having multiple disulfide bonds and...

Details Recombinant proteins having multiple disulfide bonds and... Recombinant proteins having multiple disulfide bonds and...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/30 (2006.01) C07K 17/08 (2006.01) G01N 33/532 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232601

The present invention relates to recombinant antigen binding proteins having multiple disulfide bonds useful for the preparation of immunoconjugates. In particular, this invention relates to recombinant antibodies comprising an IgG3 hinge region and lacking a CH2 constant domain. These mutated antibodies are used to bind a diagnostic or therapeutic agent through one or more reduced disulfide bonds in the antibody hinge region. Thus, the invention contemplates the use of such immunoconjugates in diagnosis and therapy.

La présente invention concerne des protéines liant des antigènes recombinés, lesquelles possèdent de multiples liaisons disulfure et sont utiles dans la préparation de conjugués immunologiques. Cette invention concerne en particulier des anticorps recombinés comportant une région charnière IgG¿3?, mais dans lesquels il manque un domaine constant CH2. Ces anticorps mutés sont utilisés afin de lier un agent diagnostique ou thérapeutique par l'intermédiaire d'une ou de plusieurs liaisons disulfure réduites situées dans la région charnière des anticorps. Cette invention concerne également l'utilisation de tels conjugués immunologiques en matière de diagnostic et de thérapie.

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