C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2399847
Antibodies are described, which are suitable for identification of .gamma.- carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while not reacting with glutamic (Glu) residues in corresponding proteins and/or peptides. Methods for the preparation and identification of said antibodies as well as methods for detection of Gla in biological fluids, tissue extracts, tissue specimens, in which methods said antibodies are used, are also described. There is also described the use of said antibodies for immunopurification of Gla-containing proteins or peptides by, for instance, immunoprecipitation or immunoaffinity chromatography.
L'invention concerne des anticorps qui conviennent pour l'identification de l'acide .gamma.-carboxyglutamique (Gla), lesdits anticorps ayant la capacité d'identifier les résidus de Gla dans les protéines et/ou peptides sans pour autant réagir avec les résidus glutamiques (Glu) dans les protéines et/ou peptides correspondantes. L'invention concerne aussi des procédés de préparation et d'identification de ces anticorps ainsi que des procédés de détection de Gla dans des fluides biologiques, extraits de tissus et spécimens de tissus qui utilisent ces anticorps. L'invention concerne également l'utilisation de ces anticorps dans l'immunopurification des protéines ou peptides contenant Gla, par exemple, au moyen de l'immunoprécipitation ou la chromatographie d'immunoaffinité.
Brown Mark Alan
Stenberg Leisa Mary
Stenflo Johan
Gowling Lafleur Henderson Llp
Protease Ab
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