Modified transferrin fusion proteins

Details Modified transferrin fusion proteins Modified transferrin fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/21 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01) C07K 14/47 (2006.01) C07K 14/505 (2006.01) C07K 14/555 (2006.01) C07K 14/605 (2006.01) C07K 14/62 (2006.01) C07K 14/705 (2006.01) C07K 14/79 (2006.01) C07K 19/00 (2006.01) C12N 15/17 (2006.01) C12N 15/20 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2495210

Modified fusion proteins of transferrin and therapeutic proteins or peptides including soluble toxin receptors, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.

L'invention concerne des protéines de fusion de transferrine modifiées et des protéines ou des peptides thérapeutiques, y compris des récepteurs de toxines solubles, à demi-vie sérique accrue ou à stabilité sérique accrue. Les protéines de fusion préférées comprennent les protéines modifiées, de sorte que la fraction transferrine ne présente pas de glycosylation ou un glycosylation réduite, qui se fixent au fer et/ou au récepteur de transferrine.

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