Conversion of delta 16-steroid to a delta 17 (20)-20-silyl...

Details Conversion of delta 16-steroid to a delta 17 (20)-20-silyl... Conversion of delta 16-steroid to a delta 17 (20)-20-silyl...

C - Chemistry, Metallurgy

07

J

C07J 51/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2051670

The present invention is a process for conversion of .DELTA.16-steroids (I), to the corresponding .DELTA.17(20)-20-silyl ether (III), by reaction with (1) a preformed copper hydride or a metal hydride reducing agent in the presence of a copper species and (2) a silylating agent. The .DELTA.17(20)-20-silyl ethers (111) are useful intermediates in the preparation of steroids useful as pharmaceuticals.

L'invention est un procédé de conversion de DELTA16-stéroïdes (I) en éthers-oxydes DELTA17(20)-20-silyliques (III) par réaction avec (1) un hydrure de cuivre préformé ou un agent réducteur à base d'hydrure métallique, en présence d'un composé du cuivre et (2) d'un agent de silylation. Ces éthers-oxydes (III) peuvent servir comme intermédiaires pour la préparation de stéroïdes utiles en pharmacie.

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