Msh peptide derivatives

Details Msh peptide derivatives Msh peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/68 (2006.01) A61K 38/34 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2060537

ABSTRACT OF THE INVENTION Compounds of formula I A ?X - Y]n I wherein A is a chelating group capable of complexing a detectable element, n is 1 or 2 X is a direct bond or a spacer group, and Y is a residue derived from a .alpha.-or .beta.-MSH peptide bearing in the 10- or 11-position a substituted side chain group A-X being linked to the terminal amino group of the peptide residue Y and the substitution on the side chain group in the 10- or 11-position being selected so that it does not significantly interfere with or impair the binding affinity of the peptide to the MSH receptors, in free form or in a salt form are useful when labelled with a detectable element in in vivo diagnostic and therapeutic applications.

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