Combination therapy to treat osteoporosis - polyphosphonates...

Details Combination therapy to treat osteoporosis - polyphosphonates... Combination therapy to treat osteoporosis - polyphosphonates...

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2198534

Disclosed is a pharmaceutical composition for preventing or treating osteoporosis containing a compound of formula I (see fig I) (wherein A is CH2 or NR; R is H or alkyl; B, D and E are each CH or N; Y is a cyclic group such as phenyl; Z1 is a divalent group such as -OCH2CH2; G is an optionally substituted amino group such as piperidino or pyrrolidino; and e is 0, 1 or 2) in combination with a polyphosphonate or a progestin.

Composition pharmaceutique pour la prévention ou le traitement de l'ostéoporose, renfermant un composé de formule I (voir fig. I) ¢où A est CH2 ou NR; R est H ou un alkyle; B, D et E sont chacun CH ou N; Y est un groupe cyclique comme le phényle; Z1 est un groupe divalent comme -OCH2CH2; G est un groupe amino avec substitution facultative, comme un pipéridino ou un pyrrolidino; e est 0, 1 ou 2! en combinaison avec un polyphosphonate ou une progestine.

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