C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/130, 195/1.2
C12N 7/01 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) C12N 15/863 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2033757
ABSTRACT OF THE DISCLOSURE What is described is a modified recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, having an internal core containing DNA from a non-pox source in a nonessential region of the poxvirus genome. The recombinant poxvirus is modified by disassociating the internal core from outer membranes of the poxvirus. The DNA codes for and expresses a gene product in a cell cultured in vitro and in a host in vivo without productive replication of the virus in the cell or in the host. What is also descried is a vaccine containing the modified recombinant poxvirus for inducing an immunological response in a host inoculated with the vaccine.
Health Research Incorporated
Smart & Biggar
LandOfFree
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