Use of negative regulation elements for nerve-specific...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) C12N 5/079 (2010.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2321220

The invention concerns novel methods and constructs for controlling nucleic acid expression, in particular methods and constructs using NRSE sequences for obtaining a targeted expression of transgenes in the nerve cells in vivo or ex vivo. The invention is particularly adapted for in vivo gene transfer applications, for instance for therapeutic or scientific approach.

La présente invention concerne de nouvelles méthodes et constructions permettant de contrôler l'expression d'un acide nucléique. En particulier, l'invention concerne des méthodes et constructions utilisant des séquences NRSE, permettant d'obtenir une expression ciblée de transgènes dans les cellules nerveuses in vivo ou ex vivo. L'invention est particulièrement adaptée à des applications de transfert de gènes in vivo, pour des approches thérapeutiques ou scientifiques par exemple.

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