C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/10 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2288375
The present invention discloses useful surfactant molecules including polypeptides, proteins, and a variety of other organic molecules, as well as methods of making and using same. Surfactant compositions, including liposomal surfactant compositions, are also disclosed. Use of the surfactant molecules of the present invention in pulmonary lavage procedures for a variety of therapeutic applications is also disclosed, including the treatment of respiratory distress syndrome; the removal of inflammatory exudate from inflamed lung tissues; and the treatment of meconium aspiration syndrome in infants.
L'invention concerne des molécules tensioactives utiles comprenant des polypeptides, des protéines et une variété d'autres molécules organiques, ainsi que des procédés de production et d'utilisation de celles-ci. Des compositions tensioactives, dont des compositions tensioactives liposomales, font aussi l'objet de cette invention. L'invention concerne également l'utilisation des molécules tensioactives précitées lors de procédés de lavage pulmonaire pour une série d'applications thérapeutiques, dont le traitement du syndrome de détresse respiratoire, l'élimination d'exsudat inflammatoire de tissus pulmonaires enflammés et le traitement du syndrome d'aspiration de méconium chez les bébés.
Cochrane Charles G.
Revak Susan D.
Fetherstonhaugh & Co.
The Scripps Research Institute
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