Peptide modulators of cellular phenotype and bi-nucleic acid...

G - Physics – 01 – N

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G01N 30/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2568644

The present invention provides a non-hybrid screening method for the identification and/or isolation of a peptide that is capable of modulating a phenotype in a cell, tissue or organism. For example, the non-hybrid screening method identifies a peptide that is derived from an organism that is unrelated to the cell, tissue or organism. Alternatively, or in addition, the non-hybrid screening method identifies a peptide thaty is capable of rescuing the cell, tissue or organism from cell death or inducing a cell, tissue or organism to grow. The present invention also provides a non-hybrid screening method for identifying a peptide that is useful for treating a disease and/or disorder.

La présente invention concerne une méthode de criblage non hybride d'identification et/ou d'isolement d'un peptide pouvant moduler un phénotype dans une cellule, un tissu ou un organisme. La méthode de criblage non hybride permet, par exemple, d'identifie un peptide dérivé d'un organisme non associé à la cellule, au tissu ou à l'organisme. En variante, ou de plus, ladite méthode de criblage non hybride permet d'identifier un peptide capable de sauver la cellule, le tissu ou l'organisme de la mort cellulaire ou d'induire la croissance d'une cellule, d'un tissu ou d'un organisme. La présente invention concerne également une méthode de criblage non hybride permettant d'identifier un peptide utilisé dans le traitement d'une maladie et/ou d'un trouble.

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