Method of encapsulating an active lipid-soluble substance by...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01)

Patent

CA 2513273

The invention relates to a method of encapsulating an active lipid-soluble substance in nanocapsules, by preparing an emulsion. The inventive method is characterised in that it consists in: (a) obtaining an aqueous phase and an oil phase; (b) raising the temperature of the two phases to a temperature greater than the phase inversion temperature; (c) mixing the two phases; (d) incorporating the active lipid-soluble substance into the lipid-soluble phase; (e) allowing the temperature to decrease to the phase inversion temperature; (f) once the phase inversion is effective and the emulsion is in a continuous aqueous phase, quenching the emulsion obtained in order to lower the temperature thereof. The invention also relates to the emulsion that can be obtained using the inventive method, said emulsion being characterised in that the average nanocapsule size is less than 300 nm.

Procédé d'encapsulation d'un principe actif liposoluble dans des nanocapsules par préparation d'une émulsion caractérisé en ce que : a) on dispose d'une phase aqueuse et d'une phase grasse, b) on élève la température des deux phases jusqu'à une température supérieure à la température d'inversion de phase, c) on effectue le mélange des deux phases, d) on incorpore le principe actif liposoluble dans la phase liposoluble, e) on laisse la température s'abaisser jusqu'à la température d'inversion de phase, f) dès que l'inversion de phase est effective et que l'émulsion est en phase continue aqueuse on trempe l'émulsion obtenue pour abaisser sa température et émulsion susceptible d'être obtenue par le procédé caractérisée en ce que la taille des nanocapsules est inférieure en moyenne à 300 nm.

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