Inhibitors of farnesyl-protein transferase

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/08 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 207/16 (2006.01) C07D 209/42 (2006.01) C07D 209/44 (2006.01) C07D 211/60 (2006.01) C07D 217/26 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2185553

The present invention is directed to compounds which inhibit farnesyl-proteine transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.

La présente invention concerne des composés qui inhibent la protéine farnésyl-transférase (Ftase) et la farnésylation de la protéine oncogène Ras. L'invention a aussi pour objet des compositions chimiothérapeutiques contenant les composés de la présente invention, et des procédés pour inhiber la protéine farnésyl-transférase et traiter le cancer.

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