Screening assays and methods of tumor treatment

Details Screening assays and methods of tumor treatment Screening assays and methods of tumor treatment

G - Physics

01

N

G01N 33/50 (2006.01) A01K 67/027 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2542215

The invention relates generally to the screening of candidate molecules for the treatment of tumor metastasis, and treatment methods using such molecules. Thus, the invention includes a method of screening comprising the steps of: (1) administering a plurality of test substances to a non-human syngeneic immunocompetent animal model bearing at least one soft tissue or bone metastasis, in the presence or absence of a primary tumor; (2) determining the effects of the test substances on the soft tissue or bone metastasis and growth of the primary tumor, if present; and (3) identifying a test substance that inhibits the growth of a soft tissue or bone metastasis, without adverse effect on the status of the primary tumor, if present.

De manière générale, la présente invention a trait au criblage de molécules candidates pour le traitement de la métastase tumorale, et des procédés de traitement mettant en oeuvre de telles molécules. Ainsi, l'invention a trait à un procédé de criblage comprenant les étapes suivantes : (1) l'administration d'une pluralité de substances de test à un modèle animal immunocompétent syngénique non humain portant au moins une métastase de tissu mou ou osseuse, en présence ou en l'absence d'une tumeur primaire ; (2) la détermination des effets des substances de test sur la métastase de tissu mou ou osseuse et la croissance de la tumeur primaire, le cas échéant; et (3) l'identification d'une substance de test qui assure l'inhibition de la croissance de la métastase de tissu mou ou osseuse, sans effet indésirable sur l'état de la tumeur primaire, le cas échéant.

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