C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/415 (2006.01) C07D 233/70 (2006.01) C07D 409/00 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2094390
A class of N-substituted imidazol-2-one compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of formula (I), wherein m is one; wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, chlorophenyl, thien- ylethyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R0 is selected from hydrido, methyl, fluoro, chloro, monofluoromethyl, difluoromethyl, trifluoromethyl, formyl, carboxyl and dimethoxymethyl; wherein R2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phe- nyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio and hydroxyalkyl; wherein each of R3, R4, R5, R6, R7, R8, R10 and R11 is hydrido; wherein R9 is selected from COOH and (II) or a tautomer thereof or a pharmaceutical- ly-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
Manning Robert E.
Reitz David B.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
LandOfFree
N-substituted imidazol-2-one compounds for treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-substituted imidazol-2-one compounds for treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted imidazol-2-one compounds for treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1385707