An ultra high-throughput opti-nanopore dna readout platform

Details An ultra high-throughput opti-nanopore dna readout platform An ultra high-throughput opti-nanopore dna readout platform

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G06F 19/20 (2011.01) C40B 30/04 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2577079

Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.

L'invention porte sur des procédés d'analyse de molécules de polymères. Ces procédés sont utilisés pour la lecture à rendement ultra élevée de molécules d'ADN et d'ARN ayant une sensibilité de molécule unique. Le procédé selon l'invention comprend (1) le dégrafage commandé électriquement de doubles brins d'ADN ou d'ARN, et (2) la lecture de l'identité (ou code) de la molécule à l'aide d'une détection de signaux d'une ou plusieurs molécules.

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