Guanidinyl- or amidinyl-substituted heterocyclic thrombin...

Details Guanidinyl- or amidinyl-substituted heterocyclic thrombin... Guanidinyl- or amidinyl-substituted heterocyclic thrombin...

C - Chemistry, Metallurgy

07

D

C07D 207/09 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07D 207/08 (2006.01) C07D 211/34 (2006.01) C07D 223/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2122397

Abstract GUANIDINYL- OR AMIDINYL-SUBSTITUTED HETEROCYCLIC THROMBIN INHIBITORS Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors are provided which have the structure Image : wherein n is 0, 1 or 2; X is S, SO, SO2 or O: R1 is -A-R2, where A is an alkyl, alkenyl, or alkynyl chain of 2 to 6 carbon atoms and R2 is guanidine, amidine, or amino; or R1 is -(CH2)p-A'-R2' where R2' is amidine and A' is an azacycloalkyl ring of 4 to 8 atoms, optionally substituted by alkyl, CO or halo; or R1 is -(CH2)p-A"-R2-, wherein R2" is quanidine, amidine or aminomethyl, and A" is aryl or cycloalkyl; and p, R3, R", R5 and R6 are as defined herein.

Affiliated with

Also associated with

Rating

Guanidinyl- or amidinyl-substituted heterocyclic thrombin... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Guanidinyl- or amidinyl-substituted heterocyclic thrombin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanidinyl- or amidinyl-substituted heterocyclic thrombin... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1385721