Process for the preparation of l-phosphinothricin by...

Details Process for the preparation of l-phosphinothricin by... Process for the preparation of l-phosphinothricin by...

C - Chemistry, Metallurgy

12

P

C12P 13/04 (2006.01) C12N 1/20 (2006.01) C12P 1/04 (2006.01)

Patent

CA 2370109

The patent application describes a process for the enzymatic chiral synthesis of L-phosphinothricin by transamination from its corresponding keto acid PPO with aspartate as amino donor. It is possible by a suitable reaction procedure to achieve a quantitative conversion on use of approximately equimolar amounts of amino donor and acceptor with complete consumption of the donor amino acid aspartate. The use of thermally stable transaminases makes a higher reaction rate and correspondingly large space/time yields possible.

Procédé de synthèse enzymatique chirale de L-phosphinothricine par transamination à partir de son acide cétonique correspondant PPO avec de l'aspartate en tant que acides aminés. Une procédure de réaction appropriée permet d'obtenir une conversion quantitative, à l'aide de quantités pratiquement équimolaires de donneur et d'accepteur d'acides aminés, l'acide aminé donneur aspartate étant complètement utilisé. L'utilisation de transaminases thermostables permet des vitesses de réaction élevées et partant, une grande efficacité pour ce qui est de l'espace et du temps.

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