C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 35/37 (2006.01) A61L 27/24 (2006.01) A61L 27/38 (2006.01) C12N 11/02 (2006.01)
Patent
CA 2652138
Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise three-dimensional matrices/biomaterials that are created from solubilized collagen compositions using controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues.
La présente invention concerne des supports de cultures cellulaires présentant un micro-environnement plus pertinent sur le plan biologique. Plus particulièrement, ces supports de cultures cellulaires comportent des matrices/des biomatériaux tridimensionnels qui sont générés par des compositions de collagène solubilisé dans des conditions contrôlées en vue d'obtenir la micro-structure et les propriétés mécaniques souhaitées. Les compositions matricielles élaborées à base de collagène purifié selon la présente invention peuvent être utilisées séparément ou combinées à des cellules en tant que constructions de greffes tissulaires destinées à améliorer la cicatrisation de tissus lésés ou malades.
Purdue Research Foundation
Smart & Biggar
LandOfFree
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