C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/55 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01)
Patent
CA 2187818
The invention provides gene delivery fusion protein (GDFPs) for use in gene transduction of target cells, such as mammalian cells. The GDFP contains a nucleic acid binding domain (NBD) that binds to a targeted nucleic acid to be transduced, fused to a gene delivery domain (GDD) that mediates or augments transfer of the targeted nucleic acid into the target cell. The GDD contains one or more components that facilitate gene delivery, including bind- ing/targetting components, membrane-disrupting components, trans- port/localization components and replicon integration components.
La présente invention concerne une protéine de fusion d'apport de gène ou "GDFP" (Gene Delivery Fusion Protein) utilisable pour la transduction de cellules cibles et notamment les cellules de mammifères. La GDFP comporte un domaine de liaison d'acide nucléique ou "NBD" (Nucleic acid Binding Domain) se liant à un acide nucléique ciblé devant subir une transduction, lequel NBD est fusionné sur un domaine d'apport de gène ou "GDD" (Gene Delivery Domain) qui facilite ou augmente le transfert de l'acide nucléique ciblé dans la cellule cible. Le GDD contient une ou plusieurs composantes favorisant l'apport de gène, qu'il s'agisse de composantes de liaison ou de ciblage, de composantes de rupture de membrane, de composantes de transport ou de localisation ou de composantes d'intégration des réplicons.
Overell Robert W.
Weisser Karen E.
Borden Ladner Gervais Llp
Targeted Genetics Corporation
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