Histidine and homohistidine derivatives as inhibitors of...

Details Histidine and homohistidine derivatives as inhibitors of... Histidine and homohistidine derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

K

C07K 5/097 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 401/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2190977

Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

L'invention concerne de nouveaux inhibiteurs d'une enzyme farnesyltransférase activant des protéines, ainsi que des procédés de préparation et des compositions pharmaceutiques desdits inhibiteurs, qui présentent une efficacité de lutte contre des maladies de prolifération des tissus, y compris le cancer et la resténose.

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