Antithrombogenic surfaces comprising immobilized heparin and...

Details Antithrombogenic surfaces comprising immobilized heparin and... Antithrombogenic surfaces comprising immobilized heparin and...

A - Human Necessities

61

L

A61L 33/10 (2006.01) C08B 37/10 (2006.01)

Patent

CA 2342991

The present invention relates to a process for preparing surface modifications having an improved antithrombogenic activity, whereby the improvement is achieved by treating heparin at elevated temperature or at elevated pH or in contact with nucleophilic catalysts such as amines, alcohols, thiols or immobilized amino, hydroxyl or thiol groups before attaching said heparin to the surface to be modified.

La présente invention concerne un procédé de préparation de modifications de surfaces présentant une activité anti-thrombogénique, cette amélioration étant réalisée par le traitement de l'héparine à température élevée, avec un pH élevé, ou avec le contact avec des catalyseurs nucléophiles tels que les amines, les alcools, les thiols ou amino immobilisé, des groupes thiols ou hydroxyles, avant de fixer ladite héparine à la surface devant être modifiée.

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