Prodrugs to thyroid hormone analogs

Details Prodrugs to thyroid hormone analogs Prodrugs to thyroid hormone analogs

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/53 (2006.01) A61P 5/16 (2006.01)

Patent

CA 2699338

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.

L'invention porte sur des composés représentés par la formule (I) : ainsi que sur des sels et esters pharmaceutiquement acceptables de ces composés, les substituants étant tels que ceux indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies telles que l'obésité, l'hyperlépidémie, l'hypercholestérolémie et le diabète et d'autres troubles apparentés et maladies apparentées, et peuvent être utiles pour d'autres maladies telles que la NASH, l'athérosclérose, les maladies cardiovasculaires, l'hyperthyroïdisme, le cancer de la thyroïde et d'autres troubles et maladies apparentés à ceux-ci.

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